25 Aug 2009 (symposium)
24-29 Aug 2009 (congress)
Turin, Italy
Supported by
  
By bridging the genotype-phenotype gap, molecular systems biology approaches have the potential to provide new insights into eminent
problems in evolutionary genetics including the adaptive landscape.
Realistic computational models of biological systems that predict
fitness correlates and their calibration with wet-lab data are vital
for progress in the emerging field of evolutionary systems biology.
This year's biannual congress of the European Society for Evolutionary Biology in Turin, Italy attracted well over 1000 participants and was divided into six parallel symposia tracks (see ESEB conference website). For the first time it featured a symposium on evolutionary systems biology. The symposium was well attended and provided an exciting opportunity for interacting with some of the leading researchers in EvoSysBio. More details below.
Full PDFs of selected talks presented at the symposium:
Talk abstracts from the official ESEB website
Poster abstracts from the official ESEB website
The following talks were presented (only the presenter's name is given here):
Invited talks
- The EMBO lecture by Laurence D. Hurst
Noise abatement and genome evolution
Laurence D. Hurst, Nizar N. Batada, Károly Kovács, Balázs Papp &
Araxi
O.
Urrutia
University of Bath, UK
PDF of presentation
- Roy Kishony
Evolution of resistance in multi-drug space
Department of Systems Biology, Harvard Medical School
Oral presentations: Systems biology
and population genetics
- Ryszard Korona
Genetic and environmental factors of fitness variation in yeast gene-deletion strains
PDF of presentation
- Ivana Gudelj, Ayari Fuentes-Hernandez, Craig MacLean, Duncan Greig & Laurence Hurst
Quantifying fitness in a public goods game
- Christian Kost
Genomic modularity facilitates adaptive evolution in Pseudomonas fluorescens
(replaced cancelled talk by Craig MacLean & Angus Buckling
The distribution of fitness effects of beneficial mutations in Pseudomonas aeruginosa)
- Pierrick Labbé, Michel Raymond, Nicolas Sidos, Mylène Weill & Thomas Lenormand
Resistance gene replacement in the mosquito Culex pipiens
PDF of presentation
Oral presentations: Cellular
network models and evolution
- Stephen S. Fong
Integration of metabolic modeling
and laboratory evolution
PDF of presentation
- Stefan Schuster
Has molar yield in metabolic
networks been maximized during evolution?
- Max B. Cooper, John
F. Brookfield & Matthew Loose
Statistical properties of evolved
gene regulatory networks- feed forward loops in Escherichia coli
PDF of presentation
Oral presentations: Computing
protein phenotypes
- Stefan Richter, Matthias
Stein, Razif R. Gabdoulline & Rebecca C. Wade
Exploring relatedness of proteins
based on electrostatic properties - application to estimation of enzyme
kinetic parameters
PDF of full presentation
Posters: Systems biology and evolutionary
genetics
- Laurence Loewe
A framework for evolutionary systems biology
- Balázs Papp, Balázs
Szappanos, Csaba Pál
Systems biology of genetic interactions in yeast
- Victor Sabarly, Christine
Dillmann, Odile Bouvet, Erick Denamur & Dominique de Vienne
Within-species genetic and environmental variability of enzymatic
kinetic parameters and concentrations
- Christian Kost, Andrew D.
Farr, Caroline Rose, Gayle C. Ferguson, Hubertus J. E. Beaumont & Paul B.
Rainey
A modular genomic architecture facilitates the repeated re-evolution of
an adaptive phenotype in Pseudomonas
fluorescens
- Károly Kovács, Laurence D.
Hurst & Balázs Papp
Stochasticity in protein levels drives colinearity of gene order and
enzymatic steps in metabolic operons of Escherichia
coli
Posters: Resistance evolution
- Balázs Bogos, Orsolya Méhi &
Csaba Pál
Impact of hierarchical structure of transcriptional regulatory networks
on the evolution of drug resistance
- Rafael
Pena-Miller, Martin Ackermann & Robert E. Beardmore
Controlling the evolution of antimicrobial resistance in a single host
- Sandra Trindade, Ana Sousa,
Francisco Dionísio & Isabel Gordo
Epistasis Between Antibiotic Resistance Mutations
- Ana Sousa & Isabel Gordo
Tempo and mode of compensatory evolution
Posters: Computational methods
- Elaine Murphy & Vincent Danos
Rule Based Modelling of Biochemical Networks
Posters: Potential fitness correlates of
interest
- Braendle
Christian, Baer Charlie & Felix Marie-Anne
Quantifying the robustness and evolvability of a developmental system
- Violeta
Munoz-Fuentes & Carles Vila
Canine genomics and the rapid generation of phenotypic diversity
- Emaresi
Guillaume, Ducrest Anne-Lyse, Simon Céline & Roulin Alexandre
Adaptive functions of melanin-based coloration, the role of melanocortins
- Tugce Bilgin, Levent M.
Kurnaz & Isil Aksan Kurnaz
Robustness of Alternate Coding Tables - A Statistical Analysis
Posters: New paradigms
- Dan Cohen
New Paradigms for Modeling Long Term Evolution and Adaptations in
Varying Selection Regimes: The elusive concepts of equiblibrium and
optimality.
- Mato Nagel
Fauceir Theory.
- Soichi Ogishima & Hiroshi
Tanaka
Systems evolutionary analysis on the putative Hox transcriptional
networks
Posters: General preparations
(To prepare the ground for potential future EvoSysBio studies this category has
to be almost as broad as biology. Successful EvoSysBio is ultimately inclusive, as it depends on work in many other disciplines.)
- Jaroslav Mráček, Luboš
Úradníček & Soňa Tichá
Phylogenetic analysis of genus Salix
- Tibela Landeka
Dragičević, Marijana Zanoški Hren, Ana Rude & Jasmina Ibrahimpašić
Nitrogen removal from landfill leachate by nitrification and
denitrification
Detailed description
Evolutionary genetics has a long history of successful quantitative modelling, especially in areas where functional molecular details can be abstracted by selection coefficients. Molecular biology has a long history of uncovering functional molecular details and has recently started to engage in quantitative modelling in the new field of molecular systems biology. We propose to bring these two fields together to help elucidate some fundamental problems in evolutionary biology that include providing a molecular basis for predicting the distribution of mutational effects and epistasis in silico. Central to this approach is the definition of fitness correlates that can be computed in molecular systems biology models and establishing their calibration to experimentally observable fitness measures.
In this symposium we aim to bring together researchers that have contributed towards such a synthesis of evolutionary genetics and functional molecular properties. We believe that the new excitement in systems biology is an excellent opportunity for progress in many fundamental evolutionary questions, if the new models that are being constructed can be extended to include fitness correlates that turn them into powerful tools for investigating the adaptive landscape. Although such realistic systems models have become increasingly available in the past few years, their application to evolutionary issues has remained limited so far. Thus, an interdisciplinary symposium on evolutionary systems biology is highly timely and could facilitate the generation of novel evolutionary research programmes. A potentially useful framework for evolutionary systems biology that centers on a research program to quantify the adaptive landscape has been described recently (Loewe 2009, A framework for evolutionary systems biology. BMC Systems Biology 3:27, Journal Link ).
Symposium organizers
Dr. Laurence Loewe
Centre for Systems Biology at Edinburgh
School of Biological Sciences, University of Edinburgh
Homepage: http://evolutionary-research.net/people/lloewe
Dr. Balazs Papp
Evolutionary Systems Biology Group
Biological Research Center
Hungary
Homepage: http://www.brc.hu/~sysbiol/
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